Oat flour pancakes

OAT1 is believed to have twelve transmembrane domains. The membrane is represented in oat flour pancakes brown.

PBB GE SLC22A6 216599 x at fs. PBB GE SLC22A6 210343 s at fs. OAT1 functions as organic anion exchanger. To prevent the loss of endogenous dicarboxylates, OAT1-positive cells also express a sodium-dicarboxylate cotransporter called NaDC3 that transports dicarboxylates back into the OAT1-positive cell. Sodium is required to drive this process. In the absence of a sodium gradient across the cell membrane, the NaDC3 cotransporter ceases to function, intra-cellular dicarboxylates are depleted, and the OAT1 transporter also grinds to a halt. Alterations in the expression and function of OAT1 play important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs.

As a result, the activity of OAT1 must be under tight regulation so as to carry out their normal functions. Nucleoside analogs are a class of antiviral drugs that work by inhibiting viral nucleic acid synthesis. Stavudine also causes severe mitochondrial DNA depletion. Combining zidovudine with stavudine does not increase the mitochondrial toxicity compared to stavudine alone.